SSU72 Antibody, HRP conjugated

Datasheet

Code	CSB-PA865091LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SSU72 Polyclonal antibody

Uniprot No.

Q9NP77

Target Names

SSU72

Alternative Names

CTD phosphatase SSU72 antibody; HSPC182 antibody; Hypothetical protein FLJ10947 antibody; PNAS-120 antibody; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 antibody; ssu72 antibody; Ssu72 RNA polymerase II CTD phosphatase homolog antibody; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) antibody; SSU72_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human RNA polymerase II subunit A C-terminal domain phosphatase SSU72 protein (1-194AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

Gene References into Functions

a hand-off model in which Ssu72 mediates a conformational transition in TFIIB, accounting for the role of Ssu72 in transcription reinitiation, gene looping, and promoter-terminator cross-talk. PMID: 29158257
Aurora B kinase directly targets Ssu72 phosphatase for regulation of sister chromatid cohesion during early mitosis. PMID: 24149858
The pSer7 phosphatase activity of Ssu72 is approximately 4000-fold lower than its pSer5 phosphatase activity toward a peptide substrate PMID: 23070812
Data suggest that Ssu72 is a novel cohesin-binding protein capable of regulating cohesion between sister chromatid arms. PMID: 20818333
crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5 phosphatase Ssu72 and a CTD Ser 5 phosphopeptide PMID: 20861839
Molecular cloning and characterization of functions of human ssu72. PMID: 15659578

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Subcellular Location

Nucleus. Cytoplasm. Note=Predominantly in the cytosol.

Protein Families

SSU72 phosphatase family

Database Links

HGNC: 25016

OMIM: 617680

KEGG: hsa:29101

STRING: 9606.ENSP00000291386

UniGene: Hs.30026

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Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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